Nucleotica Scientists Publish Breakthrough Study in The Microchemical Journal
Nucleotica's research team, led by Nina Krylova and Andrei Babenka, published a groundbreaking article in the peer-reviewed Microchemical Journal.
The study, titled "High-sensitivity label-free electrochemical genosensors for carbon nanotube plasmon-assisted detection of somatic mutations in nucleic acids from formalin-fixed paraffin-embedded tissues", presents a cutting-edge diagnostic approach with significant implications for cancer treatment.
The Microchemical Journal covers all aspects and phases of analytical chemistry, including sampling, sample pre-treatment, measurement, and data analysis. It publishes work that is at the forefront of modern analytical science.
In their publication, the Nucleotica team introduces label-free electrochemical DNA nanosensors constructed from crystalline carbon nanotube plasmonic assemblies, developed using the Langmuir–Blodgett technique. This novel platform enables high-sensitivity detection of single-nucleotide polymorphisms (SNPs) in the KRAS gene, a key target in colorectal cancer diagnostics.
Highlights of the Study
- Integration of Fast Fourier Transform (FFT) into impedance spectroscopy, introducing a novel metric: the integral value of capacitance changes.
- Successful identification of the KRAS c.35G>A mutation in DNA isolated from FFPE colorectal tumor tissues.
- Remarkable attomolar-level sensitivity and a limit of detection of just 0.33 ng/ml, enabling precise analysis even of fragmented or low-concentration DNA samples.
Importantly, this technology is already being successfully implemented by Nucleotica in the development of our proprietary diagnostics platform. It forms a critical part of our mission to deliver next-generation tools for precision oncology, with the goal of improving early detection, monitoring, and personalization of cancer treatment.
Nucleotica congratulates Nina Krylova, Andrei Babenka, and the entire scientific team on this exceptional achievement and their continued dedication to innovation at the intersection of biotechnology and medicine
